Not the theory of everything
From 2015, this is a really good Sunday read on why universal theories - of science, but perhaps of everything else - never scale, and will never scale in the future.
The advent of quantum mechanics changed everything. When quantum mechanics is combined with relativity, it turns out, rather unexpectedly in fact, that the detailed nature of the physical laws that govern matter and energy actually depend on the physical scale at which you measure them. This led to perhaps the biggest unsung scientific revolution in the 20th century: We know of no theory that both makes contact with the empirical world, and is absolutely and always true. (I don't envisage this changing anytime soon, string theorists' hopes notwithstanding.) Despite this, theoretical physicists have devoted considerable energy to chasing exactly this kind of theory. So, what is going on? Is a universal theory a legitimate goal, or will scientific truth always be scale-dependent?Lawrence Krauss